期刊名称：Egyptian Journal of Pediatric Allergy and Immunology
印刷版ISSN：1687-1642
电子版ISSN：2314-8934
出版年度：2015
卷号：13
期号：2
页码：39-44
出版社：Egyptian Society of Pediatric Allergy and Immunology
摘要：Studies that have addressed the effects of respiratory distress syndrome (RDS) on neutrophil function suggested that neutrophil functions other than the generation of the respiratory burst are not impaired. Yet, results have been confusing and in some cases contradictory. Objectives: The aim of this cross - sectional controlled study is to assess ne utrophil number and function in late preterm neonates with RDS. Methods: Thirty patients underwent clinical and laboratory evaluation including complete blood counts and tests of neutrophil functions ( CD 11 b , CD 62 L and Dihydrorhodamine 123 by flowcytometry ) in comparison to 15 healthy term controls. RDS was assessed clinically and radiologically (chest x - ray). Results: Fifty perc ent of patients ( 12 females and 18 males ) had grade II respiratory distress followed by grade III then grade I . DHR , CD 11 b and CD 62 L results were lower among the patients group ( mean ± SD : 62.1± 12.23 , 63.22 ± 11.41 , 15.03 ± 8.7 respectively ). There were no significant correlations between neutrophils count , DHR , CD 11 b and CD 62 L . Only CD 11 b was significantly lower with higher grades of RDS . Conclusion: Neonates with RDS show variable affection of neutrophil functions. Further studies are recommended to elu cidate the exact mechanisms by which RDS can affect neutrophil functions and whether these effects are associated with increased incidence of infections
