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  • 标题:Behavioral response inhibition and maturation of goal representation in prefrontal cortex after puberty
  • 本地全文:下载
  • 作者:Xin Zhou ; Dantong Zhu ; Samson G. King
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:2016
  • 卷号:113
  • 期号:12
  • 页码:3353-3358
  • DOI:10.1073/pnas.1518147113
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Executive functions including behavioral response inhibition mature after puberty, in tandem with structural changes in the prefrontal cortex. Little is known about how activity of prefrontal neurons relates to this profound cognitive development. To examine this, we tracked neuronal responses of the prefrontal cortex in monkeys as they transitioned from puberty into adulthood and compared activity at different developmental stages. Performance of the antisaccade task greatly improved in this period. Among neural mechanisms that could facilitate it, reduction of stimulus-driven activity, increased saccadic activity, or enhanced representation of the opposing goal location, only the latter was evident in adulthood. Greatly accentuated in adults, this neural correlate of vector inversion may be a prerequisite to the formation of a motor plan to look away from the stimulus. Our results suggest that the prefrontal mechanisms that underlie mature performance on the antisaccade task are more strongly associated with forming an alternative plan of action than with suppressing the neural impact of the prepotent stimulus.
  • 关键词:prefrontal ; antisaccade ; monkey ; neurophysiology ; adolescence
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