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文章基本信息

  • 标题:Inhibition Numbers of Pseudocholinesterase in Korean Adults
  • 作者:Cho, Dae Soon ; Lee, Nan Ki ; Kim, Chae Guen
  • 期刊名称:Korean Journal of Anesthesiology
  • 印刷版ISSN:2005-6419
  • 出版年度:1995
  • 卷号:29
  • 期号:2
  • 页码:233-237
  • DOI:10.4097/kjae.1995.29.2.233
  • 语种:Korean
  • 出版社:The Korean Society of Anesthesiologists,
  • 摘要:

    Pseudocholinesterase is an essential enzyme for hydrolysis of succinylcholine and some people has low activity. The pseudocholinesterase from a normal individual has a greater apparent affinity for the cholinester substrate than the enzyme from succinylcholine-sensitive individuals, who has genetic variants. The ideal situation would be one in which a single, simple test would detect and identify all the variant forms of enzyme, but no such test currently exsits. The inhibitors frequently used to identify variants are dibucaine, fluoride, chloride, urea or succinylcholine as inhibition numbers. The authors found that dibucaine, fluoride and chloride numbers in Korean adults (mean±SD, %) are 85.8±1.83, 46.5±2,05 and 3.53±1.64, respectively (substrate is butyrylthiocholine).

  • 关键词:pseudocholinesterase; inhibition; Dibucaine number; Fluoride number; Chloride number
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