In the lower abdominal surgery, it is well known that epidural anethesia inhibit endocrine response to surgical stress. We used lidocaine and morphine for epidural anesthesia and investigated the changes of serum lidocane and glucose concentration compared to general anesthesia. Also we estimated the duration of postoperative pain relief. Patients in group I received general anesthesia and patients in group II received 2% lidocaine 20 cc, patients in group III received 2% lidocaine 20 cc with morphine 4 mg. The results were as follows. 1) Blood pressure and pulse rate were increased significantly in group I but were less changed in group II and group III. 2) Blood glucose concentration increased significantly in group I but there was no significant changes in group II, group IIL 3) The duration that plasma lidocaine concentration was reached peak level was prolonged in group III but no significancy was found. 4) In group III that we adminstrated 4 mg morphine epidurally. postoperaive pain relief was sustained for about 15 hours. We conclucled that Epidural anesthesia with Morphine is more convenient during perioperative and postoperative period.