Anesthesiologists should have close relationship with muscle relaxants and their reversals in clinical practice. Nowadays, the nondepolarizaing blocker is interested more than the depolarizing blocker and its reversibility. The composition of atropine, neostigmine and glycopyrrolate has been investigated for many years in korea. This study was undertaken to investigate the effects of glycopyrrolate(7ug/kg) and pyridostigmine(200ug/kg) mixture for pancuronium reversal on the heart rate and the blood pressure during halothane and enflurane anesthesia. The results were as follows: 1) In the halothane group: significantly increased mean blood pressure as compared with the enflurane group at 2,4,6 minutes and no significant difference was found after 8 minutes. 2) In the halothane group: significantly increased pulse rate at 2 and 4 minutes and decreased after 12 minutes. 3) In the Enflurane group: significantly increased pulse rate at 2,4 and 6 minutes and no increase after 8 minutes. 4) In the halothane group: significantly decreased pulse rate as compared with the enflurane group after 6 minutes and thereafter. 6) There was no significant arrhythmia but 2 cases of the bradycardia were observed in the halothane group at 14 minutes which were treated by atropine.