We selected at random 30 normotensive patients who had received operation under the general anesthesia with intubation at Chungnam national university hospital. They were divided into 3 groups. group I (Control) had received tracheal intubation with thiopental 5mgkg-1. (n=10), group II had received tracheal intubation with fentanyl 15 ugkg-1. (n=10), group III had received tracheal intubation with fentanyl 15ugkg-1 and diazepam 0.05mgkg-1 (n=10). The changes of systolic blood pressure(SBP), diastolic blood pressure(DBP), mean arterial blood pressure (MAP), heart rate (HR), and blood sugar were compared in each group. The results were as follows: 1) In group I, endotracheal intubation caused a significant riae in SBP(p<0.01) and blood glucose (p<0.01). 2) In group Il, endotracheal intubation caused a significant rise in SBP (p<0.05) and blood glucose (p<0.01). 3) In group III, endotracheal intubation cauaed little changes in SBP, DBP, MAP, HR and blood glucose.