We have observed that the tripod pin fixation for craniotomy is frequently accompanied by tachycardia and arterial hypertension, despite an apparently uate depth of general anesthesia beforehand. The method on the stabilization of the hemodynamic response to tripod pin fixation was studied in 73 adult normotensive patients. They were divided into four groups' 1) a control group (C group), 2) a group of bupivacaine loeal infiltration (B group), 3) a group receiving fentanyl 2 mg/kg intravenously (F group), and 4) a group receiving thiopental sodium 3 mg/kg intravenously (T group). Before the tripod pin fixation, we measured systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) and heart rate (HR). After the tripod pin fixation we observed those parameters one minute interval till 7 minutes. B group and F group showed the significant stability of SBP, DBP and MAP in comparision to C group and T group. In the B group, all the parameters returned to pre-pin fixation level rapidly compared to F group. In conclusion, to prevent hemodynamic response to tripod pin fixation, bupivacaine local infilteration method is most effective in this study.