The treatment for epilepsy has been studied throughout the course of human history. However, radical treatment of epilepsy has only been discovered recently with introduction of surgical treatment until now, palliative drug administration was common practice. During the anesthetic procedure for epilepsy surgery it is necessary for the patient to be alert and to cooperate with the surgeon while mapping and subcutaneous EEG test are carried out during the surgery. For this type of procedure, a new I.V. anesthetic, propofol is considered to be an ideal anesthetic agent because propofol is a short-acting and clear headed I.V. anesthetic agent for induction as the well as the maintenance of genenral anesthesia. In this study, only propofol was administered intravenously in 20 randomiied patients scheduled for brain surgery for epilepsy treatment. The mean infusion rate was 100 mcg/kg/min to maintain a satisfactory anesthesia. For the induction of anesthesia, slightly higher doses were required. The cardiovascular effects of propofol infusion was associated with slightly decrease of systolic, diastolic and mean arterial pressures. Arterial blood gases were analyzed for the evaluation of ventilatory function. PaCO2 were 41±4.23 mmHg preoperatively, 44±5.28 mmHg 30 min. following sedation, 42±6.35 mmHg 30 min. following awakening, 46±6.37 mmHg 30 min. following resedation, 44±4.79 mmHg at 2 hours and 44±6.51 mmHg at 4 hours after resedation and 36±3.98 mmHg 30 min. following recovery. PaO2 were 101±31.3 mmHg preoperatively, 190±47.13 mmHg 30 min. following sedation, 195±32 mmHg 30 min. following awakening, 209±29.23 mmHg 30 min. and 210±34.55 mmHg at 2 hours and 190±37.36 mmHg 4 hours following resedation, and 10.2±31.36 mmHg 30 min. following. PH were 7.38 preoperatively, 7.34±0.04 following sedation, 7.34±0.03 30 min. following awakening, 7.34±0.03 at 30 min. following resedation, 7.35±0.03 at 2 hours and 7.36±0.03 at 4 hours following resedation, and 7.38±3.98 at 30 min. after recovery. The duration of anesthesia was 8.5-12 hours. The duration of propofol anesthesia ranged from 8 to 9 hours. The awakening time from the cessation of propofol infusion ranged from 3 to 17 minutes. As the result of this study, we came to the conclusion that propofol is an ideal intravenous anesthetic for brain surgery for epilepsy treatment.