Thyrold storm, when related to surgery, usually develops within 6~18 hours postoperatively, with symptoms and signs of pyrexia, marked tachycardia, susceptability to severe hypotension, and restlessness. There are a few case reports of thyroid storm related to thyroid surgery or the surgery related to non thyroid surgery with the patient of the hyperthyroidism. We have experienced anesthetic management and postoperative thyroid storm management. The patient have had brain tumor and Grave's disease which was treated with antlthyroid agents and beta-blocking agents to mate the patient euthyroid state for two weeks by the internist. The patient tolerated the two hours of general anesthesia well, but on the first postoperative day, thyroid storm was developed with symptoms and signs of dyspnea, restlessness, nausea, vomiting, diarrhea and tachycardia. After thirty minutes to start the treatment with antithyroid agents, betablocking agents, sedatives and electrolyte balance, the thyroid storm was treated and the patient was discharged on the twenty first postoperative days with healthy state.