Since it was first described in 1930 by Wolff, Parkinson and White (W-P-W), the W-P-W syndrome, in its clinical significance, is the occurrence of tachyarrythmia by accessory conduction which may result in chest pain, hypotesion, congestive failure, syncope or sudden death. It still remains one of the most difficult cardiac arrythinias to treat. We experience the successful anesthetic management of 10 patients with W-P-W syndrome for non-cardiac and cardiac surgery from January, 1971 to April, 1987 at Severance hospital. With adequate preoperative management, in spite of their syndrome, all 10 patients tolerated general anesthesia fairly well, and we did not notice any significant changes in their vital signs during the perioperative period, Among the 10 patients, one recently experienced serious case is presented. In the selection of drugs for general anesthesia in cases of W-P-W syndrome, careful consideration should be given to all drugs which affect the conduction system of the heart.