The aim of this study was to assess the potential of methanolic extract of different sunflower hybrids (FH-37, FH-106, FH237, FH-259, 331 and FH-369) as a natural antioxidants. Free radical scavenging capacity, antioxidant activity and total phenolic contents were determined using DPPH, beta carotene and Folin-Ciocalteu assays respectively. These seeds were divided into two groups one used as such while other after dehulling. FH-369 and FH-331 had the highest free radical scavenging capacity, antioxidant activity and total phenolic contents. It was also observed that seeds with hull or shell had less phenolic contents and also lower antioxidant activity. There was a direct correlation between total phenol and antioxidant activity (R2 = 0.9954, p 0.0001) which indicates that polyphenols are the main antioxidants. The present study shows that all these sunflower hybrids especially FH-369 and FH-331 are strong radical scavengers and can be considered as good sources of natural antioxidants for medicinal and commercial uses.