Cardiovascular diseases are a major killer and the occurrence of cardiovascular diseases (CVD) is related to diet which we consume. Major risk factors associated with cardiovascular diseases are physical inactivity, smoking, dietary patterns etc. The consumption of meat is also associated with cardiovascular diseases mostly due to the use of processed red meat. Mechanism involved in red meat consumption and occurrence of CVD involved the gut microbes. The major component present in red meat named L-carnitine. Gut microbes convert this compound into toxic compound into trimethyl Amine (TMO), which is further converted into another toxic compound trimethylamine-N-oxide (TMAO), which cause the atherosclerosis and leads toward heart failure and other CVD. Red meat also contain toxic N-nitroso compounds which are a major risk factors in promoting hyper tension, which in fact a major cause of CVD. Consumption of red meat is a threat towards cardiovascular diseases mostly processed red meat product. Diet is a major factor which can control the occurrence and prevention of heart diseases.