期刊名称：International Journal of Innovative Research in Science, Engineering and Technology
印刷版ISSN：2347-6710
电子版ISSN：2319-8753
出版年度：2014
卷号：3
期号：1
页码：8517
出版社：S&S Publications
摘要：The present research work describes the synthesis of new heterocyclic compounds using khellinone methyl ether (1) as a starting material. Compound (1) allowed to react with different aldehydes namely, benzaldehyde, p-methoxy benzaldehyde and p-nitro benzaldehyde to give the corresponding chalcones (2a-c). The latter compounds reacted with malononitrile, guanidine, ethylcyanoacetate and ethylacetoacetate to yield cyanopyridine, aminopyrimidine, cyanopyridone and cyclohexenone derivatives (3a-c), (4a-c), (5a-c) and (6a-c) respectively. When (2a-c) allowed to react with urea and thiourea, they gave oxopyrimidine and thioxopyrimidine derivatives (7a-c) and (8a-c). On the other hand compound (8a-c) condensed with 3-bromopropionic acid or chloroacetic acid to yield thiazinopyrimidine (9a-c) and 3- thiazolo-pyrimidine (10a-c) respectively. Compounds (8a-c) were condensed with chloroacetic acid and aromatic aldehyde to yield the aryl methylene derivatives (11a-c) which could be prepared directly by condensation of compound (10a-c) with aromatic aldehyde. The characterization of the resulting products were confirmed by FTIR, 1HNMR, MS and elemental analyses. The newly synthesized compounds were screened for their antibacterial activity against Escherichia coli, Pseudomonas aurignosa, Salmonella typhimurium, Bacillus subtilis and Staphylococcus aureus using the disc diffusion method.
