摘要：A series of Schiff base derivatives have been synthesized by condensed of isophthalaldehyde and biphenyl-4,4'-dicarbaldehyde with various hydrazones in ethanol in the presence of acetic acide as catalyst to yield the Schiff base derivatives (I-V), The structure of synthesized compounds has been established on the basis of their spectral (FT-IR, Mass, 1H, 13C-NMR, elemental analysis )data. The purity of the compounds was confirmed by TLC. All these compounds were evaluated for their In vitro activity against several microbes (Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Klebsiella pneumonia).
