摘要：Although new approaches to the early detection of cancer are continually improving, still many patients come to the health centres when the disease has become incurable. For this reason early diagnosis is crucial. Biochemical tumor markers have been attracting more and more attention in the diagnosis of malignant diseases. Acute phase reactant proteins such as C-reactive protein (CRP) and Alpha-l antitrypsin (AIAT) have been considered as biochemical tumor markers useful at initial diagnosis, staging, and monitoring of cancer diseases after surgery. A significant increase of CRP and A1AT was found in the initial stages of gastrointestinal cancer groups as compared to healthy blood donors. The concentration progressively increases with increasing severity of cancers. The aim of present study was to find the usefulness of estimation of CRP and A1AT in the early diagnosis of gastrointestinal cancers. CRP was measured by latex turbidimetry method and A1AT by turbidimetry method. Statistical analyses was done using SPSS version 10.0 (SPSS Inc., USA) and MedCalc. The levels of serum CRP and A1AT can easily be determined prior to the treatment in the patients with gastrointestinal cancers. The findings were useful in the early diagnosis of gastrointestinal cancers and in complex preoperative diagnostic procedure to estimate the advanced stage of disease initially, suggesting an opinion about the treatment of patients who had not underwent any therapeutic procedure yet.
