标题：EFFECTS OF DIFFERENT CONCENTRATION OF FENTANYL ON THE INCIDENCE AND SEVERITY OF FENTANYL-INDUCED COUGH DURING ANESTHESIA INDUCTION: A DOUBLE-BLIND CONTROLLED STUDY
摘要：fentanyl induced cough is commonly occur during anesthesia, which should be prevented in these patients. The aim of this study was to assess different concentration of fentanyl on the incidence and severity of fentanyl-induced cough during anesthesia induction.This double blind randomized clinical trial was carried out in Shahid Mohammadi Hospital of Bandar Abbas on 150 patients aged between 18 and 50 who were candidates for elective surgery. All the 150 patients were allocated into three groups of 50 patients. Two minutes after different concentration of fentanyl injection, the intensity and number of coughs were assessed. Data were entered SPSS v. 19 and was analyzed using descriptive statistics, chi square and independents sample t test. The mean age of the patients of the first, second and third group was 24.4 ± 6.8, 25.3 ± 6.8 and 24.6 ± 6.6 years, respectively. The difference of age, gender, weight, body mass index (BMI), O2 saturation level, systolic and diastolic blood pressure of the patients of the three groups were not significant. The incidence of cough was 22%, 6% and 10% among the patients of the first, second and third group, respectively. The difference between cough incidence was significant (P=0.031) and there was a significant relationship between cough intensity and fentanyl concentration (p=0.044). the results of this study indicates low dose fentanyl may be effective method for reducing incidence and severity of fentanyl induced cough during anesthesia induction
