摘要：Introduction: Sepsis is known as an ancient problem in medicine. As sepsis and its complications are responsible for lots of death in Intensive Care Unit (ICU), deferment in diagnosis and treatment can lead to increase the mortality rate. Studies on procalcitonin (PCT) as an acute phase reactant protein have been done broadly for prediction of severity and mortality in last years. Sequential Organ Failure Assessment (SOFA) score which evaluated the severity of disease is used as a factor in crucial state. AIM: This study was designed in order to assign the correlation between PCT and SOFA score as a severity determinant among patients with severe sepsis and septic shock. Methods: This cross sectional study was performed on 60 adult patients admitted in Intensive Care Unit (ICU) in Imam Reza hospital, AJA University of Medical Sciences, Tehran, Iran between August 2014 and August 2015. Assessment of severity of disease was performed by SOFA scores on day 1, 3 and 7 and the PCT level was measured on the same days. The statistical correlations were analyzed between PCT levels and SOFA score on days 1, 3, and 7. Results: There were no significant correlations found between sex, age, and weight with neither of SOFA score and PCT levels in days 1, 3, and 7. We found a positive correlation between PCT measured on days 1, 3, and 7 with SOFA Score. Conclusion: Our findings suggest that PCT could be introduced as an ideal biomarker for assessing the severity of sepsis and also higher amounts of PCT was associated with higher SOFA scores
