摘要：First syntheses of five natural 1,3-diarylpropenes (cinnamylphenols) 2 – 4 , 7 , and 8 along with synthesis of two other natural 1,3-diarylpropenes 1 and 5 and E -isomer of mucronulastyrene ( 6 ) were achieved by Friedel–Crafts alkylation as a key step. Subsequently, their anti-inflammatory effects were also investigated in lipopolysaccharide (LPS)-induced RAW264.7 macrophages. The compounds exhibited significant inhibition of inflammatory mediated nitric oxide (NO) production with no cytotoxicity except compound 8 (dalberatin B) at 10 µM concentration and IC50 values were found in the range from 4.05 to 16.76 µM.
