期刊名称：Revue de Neuropsychologie Neurosciences Cognitives et Cliniques
印刷版ISSN：2101-6739
电子版ISSN：2102-6025
出版年度：2016
卷号：8
期号：2
页码：77-85
DOI：10.1684/nrp.2016.0379
出版社：John Libbey Eurotext
摘要：Tables Authors Didier Le Gall 12 * Christophe Jarry 1 Jérémy Besnard 1 Frédérique Etcharry-Bouyx 12 Josselin Baumard 1 Mathieu Lesourd 3 François Osiurak 34 1 EA 4638, Laboratoire de psychologie des Pays-de-la-Loire, Université d’Angers, Maison de la recherche Germaine-Tillion, 5 bis, boulevard Lavoisier, 49045 Angers cedex 1, France 2 Unité de neuropsychologie, Département de neurologie, CHU d’Angers, 4, rue Larrey 49933, Angers, France 3 EA 3082, Laboratoire d’étude des mécanismes cognitifs, Université de Lyon, 5, avenue Pierre-Mendès-France, 69676 Bron cedex, Lyon, France 4 Institut universitaire de France, 1, rue Descartes, 75231 Paris cedex 05, Paris, France * Correspondance Key words: apraxia, Alzheimer's disease, knowledges, heterogeneity DOI : 10.1684/nrp.2016.0379 Page(s) : 77-85 Published in: 2016 From its beginning, at the end of the 19th century, apraxia is associated with neurodegenerative diseases. However, very little work has been done in this area; this is particularly relevant for tool use disorders. This lack of interest might be surprising given that the diagnosis of neurodegenerative diseases also requires additional deficits such as apraxia. For example, limb apraxia or conceptual apraxia are quite common in patients with Alzheimer's disease and limb-kinetic, asymmetrical, apraxia is one of the most frequent signs in corticobasal degeneration. Another important issue is that of tool use disorders and its definite impact on patients’ lives, but there are still very few studies in this field. Moreover, several theoretical questions arise regarding the nature of apraxia in these diseases. Are disorders of skilled movement in these pathologies qualitatively similar to the apraxic syndromes following left parietal damage? Are they due to global deterioration and inability to access knowledge? First, this presentation will provide a synthetic review of works on apraxia in Alzheimer's disease and an analysis of their methodological and theoretical limits. Then, we will present preliminary data from our research on apraxia in patients with mild to moderate Alzheimer's disease. Performances of these patients on our “apraxia and tool use battery” confirm the reality and heterogeneity of tool use disorders in this disease and highlight the importance of individual analysis. In order to explore more precisely the role of conceptual knowledge in object use, we will also provide evidence from semantic dementia and fronto-temporal dementia. Finally, we discuss future research directions.
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