摘要：To prevent malaria, it is necessary to increase the immune response in the body and reduce disease severity by eradicating the parasites within the body. Tomato ( Lycopersicum esculentum Mill) is believed to be able to increase the immune response to combat infection. The current study examined 5 different treatment conditions and each treatment was repeated 6 times. The negative control group (K-) was given standard nourishment, while the positive control group (K+) received both standard nourishment and chloroquine treatment. Groups P1, P2 and P3 were given standard nourishment, as well as a dose of 0.1, 1 and 10 mg/kg BW (body weight)/day tomato extract, respectively. Each group of mice was intraperitoneally infected with 107 cells/mL Plasmodium berghei . On the 8th day post infection, the mice were sacrificed and lymphocytes and macrophages were isolated and subsequently cultured. The expression levels of IL-12 and IFN-γ, as well as the macrophage phagocytosis index of the cells, were then determined. IL-12 levels were significantly different (p<0.05) between the groups that were given tomato extract (P2 and P3) and the groups that did not receive tomato extract (K-and K+). However, the mice that received 0.1 mg/kg BW tomato extract were not significantly different from those of the K- and K+ groups. The results of this study suggest that the most effective dose of tomato extract is 10 mg/kg BW.
