期刊名称：International Journal of Innovative Research in Science, Engineering and Technology
印刷版ISSN：2347-6710
电子版ISSN：2319-8753
出版年度：2014
卷号：3
期号：10
页码：17015
DOI：10.15680/IJIRSET.2014.0310084
出版社：S&S Publications
摘要：Osteoradionecrosis (ORN) defines exposed irradiated bone, which fails to heal over a period of 3–6months without evidence of residual or recurrent tumor. It is a long term and serious complication of therapeuticradiotherapy for head and neck cancer. The pathogenesis of ORN has been proposed relating it to a fibroatrophicmechanism including free radical formation, endothelial dysfunction, inflammation, microvascular thrombosis leadingto bone and tissue necrosis. Risk factors mainly include radiation related risk factors, surgery, tobacco and alcoholabuse. Removing of diseased teeth after radiotherapy is generally considered the main risk factor in ORN. Preventionof ORN is based on the preventive extractions of decayed or periodontally compromised teeth before radiotherapy.Based on the clinical staging various therapeutic protocols have been suggested. We here report a case of Bilateralmandibular ORN with discussion of clinical features, pathogenesis, preventive measures, and management of ORN.
