期刊名称：International Journal of Innovative Research in Science, Engineering and Technology
印刷版ISSN：2347-6710
电子版ISSN：2319-8753
出版年度：2014
卷号：3
期号：11
页码：17657
DOI：10.15680/IJIRSET.2014.0311080
出版社：S&S Publications
摘要：Food allergy has been extensively studied with the advancement of technology and research strategywhich gives more insight to the etiology of the condition. The comparative study of various diagnostic and therapeuticmethods are crucial to develop a comprehensive management plan for allergic reaction triggered by the accidental foodconsumption. The diagnosis is based on cumulative results from SPT, IgE titration and oral food challenge. Foodinducedallergic reaction and immunotherapy provides an alternative to the use of symptoms-relieving anti-histamineinjector. Long term study is needed to evaluate the efficacy of OIT since it is yet to be concluded that the therapyinduces permanent tolerance or simply short-term desensitization to the food. Phase II clinical trial should be carriedout for the complementary medicine approach. Latest discovery of using interferon-gamma for tolerance induction wasenlighten, but its mechanism and other strategy to prolong the tolerance effect remained to be elucidated. Multiparameterstudy should be included in future therapeutic study, which may include genetic analysis, histologicalexamination, proteomics and bioinformatics, to assess the pathophysiology and the changes at the molecular, cellularand histological level in order to better equipped us towards diagnosis and management of the condition.
