期刊名称：International Journal of Innovative Research in Science, Engineering and Technology
印刷版ISSN：2347-6710
电子版ISSN：2319-8753
出版年度：2014
卷号：3
期号：12
页码：18176
DOI：10.15680/IJIRSET.2014.0312059
出版社：S&S Publications
摘要：Gene expression indicates the present state of the cell. Samples associated with the normal and oral tissuein Homo sapiens are collected by providing different oral tissue query terms from GEO and ArrayExpress database.Manual curation is carried using Standard Operating Procedure (SOP) provided by IBAB for both normal andcancerous condition. These samples are submitted to the novel algorithm developed at IBAB, Bangalore, to validatesamples and identify oral cancer specific genes. The study retrieved 2065 samples for oral cancer condition in Homosapiens. Out of 2065 samples, genes expressed in oral cancer were 12062; genes not expressed in oral cancer were7811. The study also retrieved 838 samples for normal oral condition, out of which genes expressed in Normal oral,were 12112 and genes not expressed in Normal oral were 7812. By comparison, 518 genes were identified which wereexpressed in oral cancer and not detected in Normal oral tissue.
关键词：Gene expression; Meta analysis; oral cancer; biocuration (manual curation); biomarker
