期刊名称：International Journal of Innovative Research in Science, Engineering and Technology
印刷版ISSN：2347-6710
电子版ISSN：2319-8753
出版年度：2014
卷号：3
期号：12
页码：18330
DOI：10.15680/IJIRSET.2014.0312079
出版社：S&S Publications
摘要：Nitro explosives are toxic in nature and hence the methods of their disposal need to be improved, suchthat they do not impose any hazards to the environment. Earthworms Dicogaster curgensis, were used as modelorganisms in this study. Earthworms were exposed to the nitro explosives (tri nitro toluene and tri nitro phenol) and totheir corresponding amines, to compare the genotoxicity of the nitro and amino derivatives. It was observed that aminogroups attached to carbon atoms in the aromatic rings, aided in reduction of genotoxicity as compared to the parentnitro explosives. We confirmed that the use of filter paper contact method, followed by comet assay is a sensitivemethod to evaluate the DNA damage induced by tri-nitro toluene and tri-nitro phenol in earthworm coelomocytes. Inthis paper, we also discuss the possibility that increased toxicity of nitro aromatic explosives might be attributed to thepresence of a nitro group, specifically at 2' position in the aromatic ring.
