The role of the Enzyme Gamma Glutamyl Transferase (GGT) as a link marker to Metabolic Syndrome (MetS) in Indians is significant. The MetS is a clustering of components that reflect over nutrition, sedentary lifestyles and resultant excess adiposity. Metabolic Syndrome is posing a major public health challenge to the health systems in developed and developing countries. This study is an attempt to see the role of biochemical markers such as GGT & Blood glucose in Metabolic Syndrome in study cases of Indian population. The 405 study subjects aged between 25-65 yrs from general population in Ghaziabad, India, were taken, who attended the hospital for general checkup. GGT and Blood Glucose of subjects were evaluated. On application of ATP 3^rd criteria on the screened subject patients, they are classified. Our study found that the number of subjects having MetS was 173 (42.71% of total). In the subgroup of metabolic syndrome with diabetes, the total number of subjects was 105 (25.92%) in which age wise distribution was 26 (6.41%) in 25-45 yrs and 79 (19.50%) in 45-65 yrs. In the second subgroup of metabolic syndrome without diabetes total number of subjects was 68 (16.79%) in which age wise distribution was 16 (3.95%) in 25-45 yrs and 52 (12.83%) in 45-65 yrs. The study proposes the inclusion of biochemical parameter GGT in the criteria for defining cases of metabolic syndrome, so that more metabolic syndrome cases can be picked up at earliest. This issue is especially pertinent for the Indian patient population in whom cardiovascular disease is becoming increasingly common in both sexes and in age group of 25-65 yrs. There should be emphasis on detection of metabolic syndrome and intensification of targeted preventive strategies. In this study; there is strong evidence that GGT should be included in the case definition criteria or diagnostic criteria of Metabolic Syndrome. The study proposes the inclusion of biochemical parameter GGT in the criteria for defining cases of metabolic syndrome in Indians. So that more cases of Metabolic Syndrome can be picked up at earliest.