文章基本信息
- 标题：The Jak2 V617 Mutation Triggers Erythropoiesis And Patients Present With Good Hemoglobin Level In Idiopathic Myelofibrosis (IMF)
- 本地全文：下载
- 作者：Fatima Khanum ; Amna Khanum ; Suhaib Ahmad 等
- 期刊名称：Esculapio
- 印刷版ISSN：2309-3080
- 电子版ISSN：2309-592X
- 出版年度：2013
- 卷号：9
- 期号：1
- 页码：15
- 出版社：Services Institute of Medical Sciences, Lahore
- 摘要：Objective:
To document the impact of JAK2 mutation on hemoglobin (Hb) level in patients with IMF.
Material and Methods:Thirty five patients were studied out of which 19 were JAK2 positive and16 were JAK2 negative. Sample collection technique was purposive non-probability sampling. Variations were observed among the studied JAK2 positive and JAK2 negative patients regarding hemoglobin level.
Results:In JAK2 positive and negative patients mean hemoglobin level was 10.6g/dl and 8.6g/dl respectively (p=0.29).
Conclusion:Due to the better hemoglobin level, patients with JAK2 mutation have less transfusion requirements and are partially protected against severe anemias compared to patients with no mutation.
- 关键词：Myeloproliferative disorder; Idiopathic myelofibrosis; Hemoglobin.
