期刊名称：Journal of Radiation Research and Applied Sciences
印刷版ISSN：1687-8507
出版年度：2016
卷号：9
期号：3
页码：242-248
DOI：10.1016/j.jrras.2015.12.001
出版社：Elsevier B.V.
摘要：Abstract Background Gamma radiation produces numerous biological perturbations in cells by direct ionization of {DNA} and cellular targets and by indirect effect through damage by free radical production. Aim To study the cellular response of blood and hepatic tissue to different doses of γ-irradiation. Results Although relative viscosity and conductivity of hemoglobin were significantly elevated in rats exposed to a single dose of 2 Gy, these elevations were statistically non significant in irradiated rats exposed to 4 and 6 Gy as compared to control animals. Serum levels of pro-inflammatory cytokines were significantly elevated in addition to up-regulation of hepatic NF-кB and down-regulation of p53 and p21 in irradiated groups. Conclusion Elevated levels of hepatic NF-κB mRNA and low levels of p53 mRNA prove lack of apoptosis and induction of the inflammatory pathway in hepatic cells to face the harmful effects of the present γ-irradiated model.
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