摘要：Th e subcellular localization of Hepatitis B virus (HBV) core protein in eukaryotic cells was studied by an immunocytochemical method following expression of the HBV core (HBc) gene in the Semliki Forest virus expression system from two di. erent constructs. HBc protein showed cytoplasmic and nuclear localization when it was expressed from a construct that encoded the HBV pregenome, whereas HBc protein that was expressed from a construct encoding the HBc gene alone was found only in the cytoplasm. Th e possible reasons for this phenomenon are discussed
