摘要：Allogeneic hematopoietic stem cell transplantation (HSCT) can be a curative option for a large number of hematologic malignancies, including acute and chronic leukemias as well as indolent and aggressive lymphoid neoplasms. Over recent years reduced intensity conditioning regimen (RIC) allo-HSCT has emerged as an attractive modality to decrease toxicity. Allogeneic HCT with nonmyeloablative or reduced-intensity condi- tioning regimens has been developed and explored for the treatment of patients who are considered ineligible for myeloablative HCT because of age or medical contraindi- cations. The aim of RIC allo-HSCT is minimizing myeloablation and maximizing allogeneic immunotherapy to obtain a significant graft versus leukemia effect, without the adverse effects of intense myeloablative preparative regimens. This review assesses a critical reappraisal of the promises and the results of this procedure
