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  • 标题:Ultrasound and contrast enhanced ultrasound sonography evaluation of intestinal acute graft-vs-host disease
  • 本地全文:下载
  • 作者:E. Benedetti
  • 期刊名称:Drugs and Cell Therapies in Hematology
  • 印刷版ISSN:2281-4876
  • 出版年度:2013
  • 卷号:1
  • 期号:4
  • 页码:253-260
  • 出版社:PAGEPress Publications
  • 摘要:Intestinal acute graft-vs-host disease (I-GVHD) is a life-threatening complication after al- lografting. Non-invasive bedside procedures to evaluate extension and treatment re- sponse are still lacking. Standard ultrasound sonography (US) detects bowel wall thicken- ing (BWT) in I-GVHD and helps to identify its extension (single or multiple sites at once). Color doppler US detects blood flow at arterioles level. Contrast-enhanced ultrasound sonography (CEUS) can detect microcirculation changes (MVC) of the bowel wall at capillary level, real time, and even bedside. CEUS allows evaluating, with dedicated software, quantitatively wash-in and washout curves of blood flowing through the thick- ened bowel wall, giving time intensity curves, which help to monitor treatment response as for Chron's disease. Patients with I-GVHD with clinical relevant improvement may still have quiescent active disease. CEUS allows identifying, qualitatively and quantitatively, patients with I-GVHD with clinical improvement but with still active disease
  • 关键词:intestinal GVHD; CEUS; ultra- ; sound sonography
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