期刊名称：International Journal of Innovative Research in Science, Engineering and Technology
印刷版ISSN：2347-6710
电子版ISSN：2319-8753
出版年度：2016
期号：NCIC
页码：85
出版社：S&S Publications
摘要：Diabetes mellitus is a metabolic disorder featured by hyperglycemia and alterations in carbohydrate, andclassified as Type I and Type II. The incidence of type II diabetes has a major health risk and significant increases inthe incidence of metabolic diseases, efficient strategies for preventing and treating of these common disorders areurgently needed. This includes the development of phytopharmaceutical products or functional foods to prevent or curemetabolic diseases.Plants have been an important source of medicine with qualities for thousands of years. Mainly ontraditional remedies such as herbs for their history it has been used as a popular folk medicine. Cassia Auriculata hasmedicinal values; ethanol flower extract of this plant was analyzed using Gas chromatography Mass Spectrometry.While the mass spectra of the compounds found in the extract was matched with the National Institute of Standards andTechnology (NIST) library. Gas Chromatography Mass Spectrometry (GC-MS) analysis revealed the presence of 8compounds. In GC-MS analysis some of the phyto-compounds Screened werePreganane-3,11,12,14,20-pentol,3,12,20-triacetate 11-(hydroxyacetate),2-propenoic acid,3-(4-methoxyphenyl), ethyl ester,(E)-1-(2,6,6-trimethylcyclohex-1-en-1-yl)undec-1-ene-3,6-dione. These compounds were analyzed for anti-diabetic activities with their protein targets usingMolecular docking studies. Docking results showed best Glide energy, Docking score, H-bonding interactionscompared with molecular targets and has the potential to prevent or treat type 2 diabetes and related disorders.
