期刊名称：International Journal of Innovative Research in Science, Engineering and Technology
印刷版ISSN：2347-6710
电子版ISSN：2319-8753
出版年度：2013
卷号：2
期号：6
页码：2194
出版社：S&S Publications
摘要：Hot Melt Extrusion (HME) is well known process for the Plastic Industries but it is well accepted by thepharmaceutical industries for the last three decays. With the use of HME we can increase solubility and bio-availabilityof the API. HME has proven to be a robust method of producing numerous drug delivery systems like modified,controlled and targeted drug delivery systems.HME is a solvent free process that achieves solid molecular dispersionsby a melt blending process, in which the API is dispersed and or dissolved into a polymeric matrix. HME is anexcellent alternative to other conventionally available techniques such as roll spinning and spray drying. In This paperwe review about the types of Extruder, solid dispersion and Application of the HME to the pharmaceutical industries.
关键词：Hot melt extrusion(HME);Targeted drug Delivery;solid dispersion;Bioavailability
