期刊名称：International Journal of Innovative Research in Science, Engineering and Technology
印刷版ISSN：2347-6710
电子版ISSN：2319-8753
出版年度：2013
卷号：2
期号：10
页码：5253
出版社：S&S Publications
摘要：The acquired immunodeficiency syndrome (AIDS) is a result of human immunodeficiency virus (HIV) infectionwhich leads to severe suppression of immune functions. Numerous plant derived compounds have been found to inhibitdifferent steps in the HIV replication cycle. Sonchus oleraceus is belongs to Asteraceae family have some medicinalproperty. The plant is a rich source of many biotic compounds which are of medicinal importance. The study wasundertaken to investigate the anti-HIV and anti-bacterial activities of coumarin compounds extracted from the Sonchusoleraceus. Microwave assisted extraction method is followed for the extraction process using three solvents i.e. ethanol,methanol and water at different temperature for 5 min followed by one or two cycle extraction method. The obtainedextracts were subjected to identification of coumarin using three different methods via, FeCl3, fluorescence method andother coumarin test. Extracts were also subjected to phytochemical analysis to check the presence of other phytochemicalcompounds. Screening of coumarin compound for the inhibitory action against protease enzymes involve in the replicationof HIV.The methanol extracts of Sonchus oleraceushave shown significant inhibition of protease activity as compared tostandard (lopinavir).
