期刊名称：International Journal of Innovative Research in Science, Engineering and Technology
印刷版ISSN：2347-6710
电子版ISSN：2319-8753
出版年度：2013
卷号：2
期号：12
页码：7918
出版社：S&S Publications
摘要：The methanolic leaf extract of BrugmansiasuaveolensBercht. &Presl.was subjected for scientific investigation to support its traditional use as wound healer. Wound healing activity was evaluated in different concentratio ns prepared as an ointment in sodium alginate using five groups of six Wistaralbino male rats in each model with povidone iodine (5%) as the standard drug. Wound healing was assessed by a rate of wo und contraction, tensile strength and histological changes. The results demonstrate high rate o f wound contraction, higher wound breaking strength in experimental animals treated with 50 mg kg - 1 of methanolic extract as co mpared to control and standard povidone iodine. These findings were further confirmed by histological examination of granulation tissue with a lesser number of chronic inflammatory cells, decreased edema and increased collagenat ion than the corresponding controls. However, effectiveness o f plant extract's wound healing property needs to be further verified before being considered for clinical purpose.
