期刊名称：International Journal of Innovative Research in Science, Engineering and Technology
印刷版ISSN：2347-6710
电子版ISSN：2319-8753
出版年度：2013
卷号：2
期号：12
页码：7750
出版社：S&S Publications
摘要：The aim of the present investigation was to evaluate the anti-rheumatic properties of methanolic extracts of theaerial parts and roots of the plant Clerodendrum serratum L. (Verbenaceae) using experimental animal models. The antirheumaticactivity of the methanolic extracts was studied based on the effects on carrageenan-induced rat paw oedema. Thepreliminary phytochemical screening was carried out for the presence and absence of alkaloids, steroids, proteins,flavonoids, saponins, carbohydrates, tannins, fats and oils. The extracts in dose level 2000 mg/kg orally were used in antirheumaticstudies. The methanolic extracts of aerial parts and roots of Clerodendrum serratum L. produced significantanti-rheumatic activity in a dose-dependent manner (200 mg/Kg and 400 mg/Kg body weight) to that of the standard drugindomethacin (10 mg/Kg). The extracts exhibited inhibitory effect in carrageenan-induced hind paw oedema in rats with allthe doses used when compared to the control group. The results obtained indicate that the crude extracts of the aerial partsand roots of the plant Clerodendrum serratum L. possess potential anti-rheumatic activity by supporting the folkloric useof the plant to treat various inflammatory conditions.
关键词：Clerodendrum serratum L.; anti-rheumatic; carrageenan; Rat paw oedema
