首页    期刊浏览 2024年11月24日 星期日
登录注册

文章基本信息

  • 标题:The Effect of Small Dose of Glycopyrrolate on the Heart Rate in the Anesthetized, and Comatose Patient
  • 本地全文:下载
  • 作者:Kang, Chul Su ; Im, Woong Mo ; Kim, Young Ho
  • 期刊名称:Korean Journal of Anesthesiology
  • 印刷版ISSN:2005-6419
  • 出版年度:1982
  • 卷号:15
  • 期号:4
  • 页码:452-457
  • DOI:10.4097/kjae.1982.15.4.452
  • 语种:Korean
  • 出版社:The Korean Society of Anesthesiologists,
  • 摘要:

    Glycopyrrolate(Robinul) is a potent anticholinergic drug. Being a quaternary ammonium compound, it dose not cross the blood-brain barrier and thus dose not have the central effects. It has been shown that glycopyrrolate has a pharmacologic properties similar to that of atropine, belladonna alkaloid, but it has lesser effect on the heart rate than that of atropine. The author administered a small dose of glycopyrrolate intravenously to 18 people who were awake, 21 compatous cases and 17 halothane anesthetized cases. The effect on the heart rate in these 3 groups was compared. The results are as follows: 1) In the awake state, glycopyrrolate(0.1mg) produced a slight decrease in the heart rate. 2) In the comatose state, glycopyrrolate(0.1mg) produced a slight increase in the heart rate. 3) In the halothane anesthetized state, glycopyrrolate(0.1mg) produced a significant increase in the heart rate. 4) In the comatose state, the absence of bradycardia after a small dose of glycopyrrolate is similar to a small dose of atropine. Therefore we suggest that bradycardia after glycopyrrolate and atropine is caused by sympathetic ganglion block.

国家哲学社会科学文献中心版权所有