期刊名称：Journal of Advanced Veterinary and Animal Research
印刷版ISSN：2311-7710
出版年度：2014
卷号：1
期号：2
页码：50-57
出版社：Bangladesh Agricultural University, Faculty of Veterinary Science
摘要：Hibiscus (H.) sabdariffa (commonly known as “Karkadeh” in Arabic) is widely used in various pharmacological applications in Sudan. The present study was carried out to investigate the anti-inflammatory and analgesic activities of H. sabdariffa seed extracts using rat models. In acute anti-inflammatory models, oral administration of petroleum ether extract of H. sabdariffa seeds inhibited the hind paw edema (p<0.01) which was induced by carrageenan. The petroleum ether extract exhibited significant (p<0.01) inhibition of vascular permeability in rats induced by intraperitoneal injection of acetic acid (0.6%). In cotton pellet granuloma method, the petroleum ether extract of H. sabdariffa seed showed significant inhibition of granuloma. The extract reduced (p<0.001) abdominal constrictions which was induced by injection of acetic acid (0.7%). Analysis of seed oil of H. sabdariffa using Gas Chromatography revealed the presence of three fatty acids; these were linolelaidic acid, arachidic acid, and palmitic acid. In conclusion, H. sabdariffa seeds possess anti-inflammatory and analgesic activities in rat model. DOI: http://dx.doi.org/10.5455/javar.2014.a13 J. Adv. Vet. Anim. Res., 1(2): 50-57, June 2014
关键词：Anti-inflammatory;Analgesic;Fatty acid;Hibiscus sabdariffa seed;Rat model
