期刊名称：ANADOLU UNIVERSITY JOURNAL OF SCIENCE AND TECHNOLOGY –C Life Sciences and Biotechnology
印刷版ISSN：2146-0213
出版年度：2011
卷号：1
期号：1
页码：83-94
DOI：10.18036/btdc.55893
语种：English
出版社：Anadolu University
摘要：In this study, three different 9-Substituted phenantrene derivatives that were synthesized to be used as basic matter for drugs were tested for their mutagenic potency in strains TA 98 and TA 100 of Salmonella typhimurium by using Ames test. Therefore, both strains were tested in the absence or presence of S9 metabolic activation, for five different doses of each test substances in two paralel independent experiments. In the absence of metabolic activation, while only one of the compounds were causing frame-shift mutations, two of them were determined to induce base pair substitution mutations. In the presence of metabolic activation, while two of the compounds were mutagenic for TA 98, base pair substitution mutations were not detected for any of the substances. Each of the compounds tested were found to be mutagenic for at least one strain in the presence or absence of S9.
