期刊名称：ANADOLU UNIVERSITY JOURNAL OF SCIENCE AND TECHNOLOGY –C Life Sciences and Biotechnology
印刷版ISSN：2146-0213
出版年度：2011
卷号：1
期号：2
DOI：10.18036/btdc.60218
语种：English
出版社：Anadolu University
摘要：In the present study, a series of chalcones were prepared by Claisen Schmidt condensation as starting compounds and 2-pyrazoline derivatives have been synthesized by the reaction of chalcones with thiosemicarbazide. Their structures have been confirmed by IR, 1H-NMR, mass spectral data and elemental analysis. These synthesized 2-pyrazoline compounds have been tested in vivo anticonvulsant activity by using pentylenetetrazole (PTZ) induced seizure and maximal electroshock (MES) seizure tests at a dose of 50 mg/kg. None of the compounds have in vivo anticonvulsant properties in PTZ test whereas some compounds showed in vivo anticonvulsant activity in MES test. Therefore, 2-pyrazoline compounds have a promising in vivo anticonvulsant activity especially on generalized absence seizures.
