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  • 标题:Genetic screening for multiple endocrine neoplasia syndrome type 1 (MEN-1): when and how
  • 本地全文:下载
  • 作者:Alberto Falchetti
  • 期刊名称:F1000 Biology Reports
  • 电子版ISSN:2051-7599
  • 出版年度:2010
  • 卷号:2
  • DOI:10.3410/M2-14
  • 语种:English
  • 出版社:Faculty of 1000 Ltd
  • 摘要:Multiple endocrine neoplasia syndrome type 1 (MEN1) syndrome has benefited from the identification of the gene whose mutations account for the genetic susceptibility to develop endocrine tumors. Asymptomatic MEN1 mutant carriers need to be clearly recognized because the gene-related mutations confer a high risk of multiple primary cancers, occur at younger ages, and affect multiple family members who inherit the cancer-predisposing genetic mutation.
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