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  • 标题:The cerebellum: from motor diseases to autism
  • 作者:Sébastien Roux ; Jean-Louis Bossu
  • 期刊名称:Revue de Neuropsychologie Neurosciences Cognitives et Cliniques
  • 印刷版ISSN:2101-6739
  • 电子版ISSN:2102-6025
  • 出版年度:2016
  • 卷号:8
  • 期号:3
  • 页码:182-191
  • DOI:10.1684/nrp.2016.0385
  • 出版社:John Libbey Eurotext
  • 摘要:Autism is a neurological disorder with severe behavioral consequences grouped under the term: autism spectrum disorders. Its origin can be genetic but in most cases autism is regarded as an idiopathic disease. The link between dysfunction of some neural networks and autism has not been clearly established and the pathophysiological mechanisms associated with autism remain unknown. The pathologies of the cerebellum in some cases of autism have been known for over 20 years. Beyond the major role of the cerebellum in the control of balance, motor coordination and motor learning, we know that the little brain ( cerebellum in Latin) is also involved in some complex functions such as the regulation of emotion, and in language learning. The anatomical and functional maturation of the cerebellum is mainly postnatal, so it is likely to play a role in the cognitive development of the child. This review summarizes the clinical, pathological and imaging knowledge as well as data in animal models, which emphasize the importance of the cerebellum in autism. Finally, this review proposes some lines of research on the major role of the cerebellum in autism.
  • 关键词:autism; cerebellum; neuropathology; Purkinje's cell
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