摘要：The role of spatial arrangements on the spread and management
strategies of a cholera epidemic is investigated. We consider the
effect of human and pathogen movement on optimal vaccination
strategies. A metapopulation model is used, incorporating a susceptible–infected–recovered system of differential equations coupled
with an equation modelling the concentration of Vibrio cholerae in
an aquatic reservoir. The model compared spatial arrangements and
varying scenarios to draw conclusions on how to effectively manage
outbreaks. The work is motivated by the 2010 cholera outbreak in
Haiti. Results give guidance for vaccination strategies in response to
an outbreak.
关键词：Optimal control theory ; ordinary differential equations ; epidemiology
