期刊名称：International Journal of Occupational Hygiene
印刷版ISSN：2008-5109
电子版ISSN：2008-5435
出版年度：2013
卷号：5
期号：4
页码：177-183
语种：English
出版社：Tehran University of Medical Sciences
摘要：Acetonitrile used as a solvent in manufactures and affects to central nervous system from inhalation exposure. The aim of this study was to develop a micro-solid phase extraction method for the determination of acetonitrile in the air matrix. The sampling was performed with a small diameter fused silica fiber coated with a thin film of stationary phase and was subsequently desorbed and analyzed by gas chromatograph equipped with a flame ionization detector (GC/FID). The effects of laboratory and sampling parameters were investigated and applied to the determination of acetonitrile in air matrix. The Carboxen/PDMS as the coating fiber showed better analytical performances compared to the PDMS fi ber. Analysis of the data by ANOVA test at a 0.05 level of accuracy showed that the peak area of the sampler was significantly affected by temperature and humidity so that the optimum temperature was 20°C and the optimum humidity was 35%. Besides, the limit of detection (LOD) and limit of quantification (LOQ) for acetonitrile in the GC system were 0.05 and 0.15 μg/ml, respectively. The solid phase microextraction (SPME) has been shown a suitable technique for sampling and analysis of acetonitrile in air. There was a good correlation between the SPME and national institute occupational safety and health (NIOSH) 1010 method under the optimum conditions.
