摘要：This study aimed to compare the acute effect of different fast food types on appetite regulatory hormones. This was a randomized, cross over design study. After ten-hour fasting, sixteen obese participants (Body Mass Index 33.6 ± 4.8 kg/m2) received Indonesia Fast Food (IFF) followed Western Fast Food (WFF) after 1 week wash out. Both of fast foods have similar energy content but higher fat content on WFF vs IFF. Plasma ghrelin, Peptide YY (PYY) and Cholecystokinin (CCK) were measured at 30, 60 and 120 minutes after ingestions. The investigation revealed that the change of plasma ghrelin level was lower on participant consuming WFF in 120 minutes vs IFF (P < 0.05). The change of plasma PYY showed significantly higher among participant on 60 minutes following WFF vs IFF (P < 0.05). The change of plasma CCK level is lower in 30, 60 and 120 minutes after consuming WFF vs IFF (all, P < 0.001). The appetite response regarding “desire to eat” was higher after consuming IFF vs WFF. This study suggested that IFF induced feeling “want to eat” higher than WFF also induced the increasing orexigenic hormone, ghrelin, but the effects on the anorexigenic hormone (PYY) and CCK were opposite.
