期刊名称：Brain. Broad Research in Artificial Intelligence and Neuroscience
印刷版ISSN：2067-3957
出版年度：2010
卷号：1
页码：80-90
语种：English
出版社：EduSoft publishing
摘要：The experimental study objective was the development of chewable tablets with the calcium complex association, the minerals and vitamin D3 for children, subject to the rules as stipulated by the Romanian Pharmacopoeia Xth edition. Generating sources of calcium, used as raw materials in the preparation of these tablets are natural products represented by complex mineral rich in calcium - Lactoval (R) HiCal (ratio of calcium and phosphorus is 2,2:1, report the same as breast milk) and 30% bovine colostrums [1, 3], making the absorption of calcium should be increased. Also, in order to fix and better absorb calcium in the body was added to make the preparation of these chewable tablets and vitamin D3. Was chosen as a method of preparing direct compression. Excipients for direct compression are diluents-binder-disaggregated. They are unitary excipients or co-processed products, multi-processed excipients together to meet those properties: microcrystalline cellulose (Vivapur 102) Ludipress, lactose (Tablettose 80), Kollidon CL Isomalt DC 100. Was also added to a lubricant (magnesium stearate) and sweetener and flavoring to carry out the preparation of tablets and after 30 days as provided Romanian Pharmacopoeia Xth and its 2001 supplement, which comprises: organoleptic control, uniformity of weight, strength, disintegration and their friability. Working method chosen and make the appropriate choice leads to tablets in terms of quality standards officinal.
关键词：chewable tablets, calcium complex association, vitamin D3, direct compression method
