文章基本信息

标题：The study of in Vitro Interaction of Ciprofloxacin with Paracetamol and Zinc in Aqueous Medium
其他标题：The study of in Vitro Interaction of Ciprofloxacin with Paracetamol and Zinc in Aqueous Medium
本地全文：下载
作者：M. R. Ahsan ; M. Z. Sultan ; F. M. Aamjad 等
期刊名称：Journal of Scientific Research
印刷版ISSN：2070-0237
电子版ISSN：2070-0245
出版年度：2012
卷号：4
期号：3
页码：701-708
DOI：10.3329/jsr.v4i3.8709
语种：English
出版社：Rajshahi University
摘要：Concurrent administration of more than one drug is a common practice in medical science and in such case one drug may affect the pharmacology of another drug. Ciprofloxacin is a commonly used antibiotic in Bangladesh and frequently prescribed with paracetamol and zinc salt for concomitant use in patients suffering from infections. Therefore, the interaction of ciprofloxacin with paracetamol and zinc salt was studied in vitro at pH 1.2, 6.8 and 7.4 which are related to gastric, intestinal juices and blood, respectively. Analysis of drug-drug and drug-metal complexation was carried out by using UV/VIS spectrophotometer as well as the conductometric titration. It was observed that ciprofloxacin formed complex with paracetamol and zinc at pH 1.2.© 2012 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.doi: http://dx.doi.org/10.3329/jsr.v4i3.8709 J. Sci. Res. 4 (3), 701-708 (2012)
关键词：Pharmacy;Ciprofloxacin; Paracetamol; Zinc sulfate; Drug-drug interaction; Drug-metal interaction; Complexation.