期刊名称：The International Journal of Occupational and Environmental Medicine
印刷版ISSN：2008-6520
电子版ISSN：2008-6814
出版年度：2016
卷号：7
期号：2
页码：107-15
DOI：10.15171/ijoem.2016.612
语种：English
出版社：National Iranian Oil Company (NIOC) Health Organization
摘要：Background: Occupational exposure to excessive level of copper results in many adverse health effects.Objective: To measure pulmonary function, oxidative stress, and extent of DNA damage in workers of a copper processing industry.Methods: 30 men working in a copper processing industry and 30 men matched for age and socioeconomic status (comparison group) were included in this study. Pulmonary function test parameters were measured for all participants. Serum malondialdehyde (MDA), ferric reducing ability of plasma (FRAP), glutathione (GSH) content in RBCs and 8-OHdG were assayed by ELISA. Extent of DNA damage in leucocytes was assayed by comet assay.Results: Pulmonary function parameters, FVC, FEV1, PEFR, and MVV measured in workers were significantly (p<0.05) lower than those observed in the comparison group. Compared to the comparison group, MDA was significantly (p=0.002) increased in studied workers; TAOC (p=0.017), and GSH (p=0.020) were significantly lower in workers than the comparison group. There was significant DNA damage in leucocytes in workers compared to the comparison group (difference in olive tail moment p<0.001). PEFR, FEF25-75%, and MEF50% were negatively correlated with MDA.Conclusion: The observed DNA damage would be due to increased oxidative stress resulting from excessive exposure to copper.
关键词：Lung; Respiratory function tests; Oxidative stress; DNA damage; Copper; Miner
