文章基本信息
- 标题:Antitumor Activity of Diospyros peregrina on Ehrlich Ascites Carcinoma in Mice
- 其他标题:Antitumor Activity of Diospyros peregrina on Ehrlich Ascites Carcinoma in Mice
- 本地全文:下载
- 作者:A. B. Raju ; Venu Gopal Y ; Ravindranath A 等
- 期刊名称:Journal of Scientific Research
- 印刷版ISSN:2070-0237
- 电子版ISSN:2070-0245
- 出版年度:2011
- 卷号:3
- 期号:2
- 页码:413-419
- DOI:10.3329/jsr.v3i2.6787
- 语种:English
- 出版社:Rajshahi University
- 摘要:The methanol extract of Diospyros peregrina (Ebenaceae) bark (MEDP) were evaluated for antitumor activity against Ehrlich ascites carcinoma (EAC)-bearing swiss albino mice. The extract was administered at the doses of 200 and 400 mg/kg body weight per day for 14 days after 24 h of tumor inoculation. After the last dose and 18 h fasting, the mice were sacrificed. The present study deals with the effect of MEDP on the growth of transplantable murine tumor, life span of EAC-bearing hosts and hematological profile MEDP caused significant (P < 0.01) decrease in tumor volume, packed cell volume, and viable cell count; and it prolonged the life span of EAC-tumor bearing mice. Hematological profile converted to more or less normal levels in extract-treated mice. The results indicate that MEDP exhibited significant antitumor activity in EAC-bearing mice. Keywords: Diospyros peregrina; Ehrlich ascites carcinoma; Antitumor. © 2011 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved. doi:10.3329/jsr.v3i2.6787 J. Sci. Res. 3 (2), 413-419 (2011)
- 关键词:Pharmacy; Pharmacology;Diospyros Peregrina; Ehrlich ascites Carcinoma; Antitumor