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标题：Antidiabetic and Hypolipidemic Effects of Different Fractions of Catharanthus Roseus (Linn.) on Normal and Streptozotocin-induced Diabetic Rats
其他标题：Antidiabetic and Hypolipidemic Effects of Different Fractions of Catharanthus Roseus (Linn.) on Normal and Streptozotocin-induced Diabetic Rats
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作者：M. A. Islam ; M. A. Akhtar ; M. R. Islam 等
期刊名称：Journal of Scientific Research
印刷版ISSN：2070-0237
电子版ISSN：2070-0245
出版年度：2009
卷号：1
期号：2
页码：334-344
DOI：10.3329/jsr.v1i2.1075
语种：English
出版社：Rajshahi University
摘要：The antidiabetic and hypolipidemic effects of petroleum-ether, ethyl acetate and chloroform fractions from ethanolic extract of the leaves of Catharanthus roseus (C. roseus) were investigated in normal and streptozotocin-induced diabetic rats (SIDRs). Single doses (150 mg/kg, i.p.) of C. roseus extracts in the fasting blood glucose (FBG) levels were determined in normal and SIDRs on 0, 1, 2, 3, 6, 10, 16, and 24th hours and serum triglyceride (TG) and serum total cholesterol (TC) levels were determined after 24th hour. In normoglycemic rats and in SIDRs, petroleum-ether and ethyl acetate fraction of C. roseus reduced blood glucose level significantly. In case of hypolipidemic effects, all fractions reduced serum total cholesterol but the ethyl acetate fraction of C. roseus was the most effective. All fractions of C. roseus reduced serum triglyceride level but the ethyl acetate fraction reduced triglyceride level at the highest. The antidiabetic and hypolipidemic activities were compared to metformin HCl (150 mg/kg). Of all the three fractions, ethyl acetate fractions were the best in activity. Ethyl acetate fraction of C. roseus was found to contain flavonoids and alkaloids. The mechanism underlying the antidiabetic activity is probably increased glycogenesis, decreased gluconeogenesis or decreased absorption of glucose from intestine. Keywords: Catharanthus roseus; Antidiabetic; Hypolipidemic; Streptozotocin-induced diabetic rat.© 2009 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.DOI: 10.3329/jsr.v1i2.1075
关键词：Pharmacy and Pharmacology;Catharanthus roseus; antidiabetic; hypolipidemic; streptozotocin-induced diabetic rat