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标题：In-vitro Studies of Pentoxifylline Controlled-Release from Hydrophilic Matrices
其他标题：In-vitro Studies of Pentoxifylline Controlled-Release from Hydrophilic Matrices
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作者：B. M. Rahman ; M. A. Islam ; M. I. I. Wahed 等
期刊名称：Journal of Scientific Research
印刷版ISSN：2070-0237
电子版ISSN：2070-0245
出版年度：2009
卷号：1
期号：2
页码：353-362
DOI：10.3329/jsr.v1i2.1080
语种：English
出版社：Rajshahi University
摘要：Methocel K15 MCR (a modified hydroxypropylmethylcellulose) matrix tablets of pentoxifylline using microcrystalline cellulose (MCC), starch and lactose were prepared by wet granulation process. There was no significant difference in drug release between the hydrophilic matrices when the Methocel K15 MCR concentration was modified in low percentage. The release of pentoxifylline was influenced by the presence of microcrystalline cellulose, and by the different concentrations of starch and lactose. The data obtained proved that the formulation with 12.5% Methocel K15 MCR and 20% lactose is more useful for a controlled release pentoxifylline, due to the percentage released after 8 hours is nearly to 65%. There was no significant change on release profile after three months storage of tablets. The best-fit release kinetics was achieved with the Higuchi model, followed by the first-order plot.Keywords: Pentoxifylline; Controlled release; Methocel K15 MCR.© 2009 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.DOI: 10.3329/jsr.v1i2.1080
关键词：Pharmacy and Pharmaceutics;Pentoxifylline; Controlled release; Methocel K15 MCR.